Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Paul J Lucassen; Carlos P Fitzsimons; Evgenia Salta; Mirjana Maletic-Savatic

doi:10.1016/j.bbr.2019.112458

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

Paul J Lucassen, Carlos P Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic

Netherlands Institute for Neuroscience (NIN)

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Abstract

In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.

Original language	English
Pages (from-to)	112458
Journal	Behavioural Brain Research
Volume	381
DOIs	https://doi.org/10.1016/j.bbr.2019.112458
Publication status	Published - 2020

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abstract = "In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential - understanding its contribution to human hippocampal functions and related disorders like depression and dementia.",

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Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

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