Adult neurogenesis: New neurons, new opportunities

Birte Doludda; Warsha Barde; Francesco D'Egidio; Carlos P Fitzsimons; Jonas Frisén; Fred H Gage; Sebastian Jessberger; Orly Lazarov; D Chichung Lie; Paul J Lucassen; Chiara de Lucia; Evgenia Salta; Hongjun Song; Juan Song; Sandrine Thuret; Tomohisa Toda; Gerd Kempermann

doi:10.1016/j.stem.2026.01.014

Adult neurogenesis: New neurons, new opportunities

Birte Doludda
, Warsha Barde
, Francesco D'Egidio
, Carlos P Fitzsimons
, Jonas Frisén
, Fred H Gage
, Sebastian Jessberger
, Orly Lazarov
, D Chichung Lie
, Paul J Lucassen
, Chiara de Lucia
, Evgenia Salta
, Hongjun Song
, Juan Song
, Sandrine Thuret
, Tomohisa Toda
, Gerd Kempermann

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

Original language	English
Pages (from-to)	382-392
Number of pages	11
Journal	Cell Stem Cell
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2026.01.014
Publication status	Published - 05 Mar 2026

Keywords

Neurogenesis/physiology
Humans
Neurons/cytology
Animals
Hippocampus/cytology
Adult
Neural Stem Cells/cytology

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10.1016/j.stem.2026.01.014

Doludda2026Final published version, 1.92 MBLicence: CC BY

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abstract = "The 38 currently registered clinical trials with the keyword {"}adult neurogenesis{"} indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.",

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AU - Doludda, Birte

AU - Barde, Warsha

AU - D'Egidio, Francesco

AU - Fitzsimons, Carlos P

AU - Frisén, Jonas

AU - Gage, Fred H

AU - Jessberger, Sebastian

AU - Lazarov, Orly

AU - Lie, D Chichung

AU - Lucassen, Paul J

AU - de Lucia, Chiara

AU - Salta, Evgenia

AU - Song, Hongjun

AU - Song, Juan

AU - Thuret, Sandrine

AU - Toda, Tomohisa

AU - Kempermann, Gerd

PY - 2026/3/5

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AB - The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

KW - Neurogenesis/physiology

KW - Humans

KW - Neurons/cytology

KW - Animals

KW - Hippocampus/cytology

KW - Adult

KW - Neural Stem Cells/cytology

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Adult neurogenesis: New neurons, new opportunities

Abstract

Keywords

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