Advancing lung organoids for COVID-19 research

Jelte van der Vaart, Mart M Lamers, Bart L Haagmans, Hans Clevers

Research output: Contribution to journal/periodicalBook/Film/Article reviewScientific

Abstract

The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

Original languageEnglish
JournalDisease Models & Mechanisms
Volume14
Issue number6
DOIs
Publication statusPublished - 01 Jun 2021

Keywords

  • Animals
  • COVID-19/epidemiology
  • Humans
  • Lung/virology
  • Models, Biological
  • Organoids/virology
  • Pandemics
  • Pulmonary Alveoli/virology
  • Research Design/trends
  • SARS-CoV-2/pathogenicity

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