Advancing lung organoids for COVID-19 research

TY - JOUR

T1 - Advancing lung organoids for COVID-19 research

AU - van der Vaart, Jelte

AU - Lamers, Mart M

AU - Haagmans, Bart L

AU - Clevers, Hans

N1 - © 2021. Published by The Company of Biologists Ltd.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

AB - The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments.

KW - Animals

KW - COVID-19/epidemiology

KW - Humans

KW - Lung/virology

KW - Models, Biological

KW - Organoids/virology

KW - Pandemics

KW - Pulmonary Alveoli/virology

KW - Research Design/trends

KW - SARS-CoV-2/pathogenicity

U2 - 10.1242/dmm.049060

DO - 10.1242/dmm.049060

M3 - Book/Film/Article review

C2 - 34219165

SN - 1754-8403

VL - 14

JO - Disease Models & Mechanisms

JF - Disease Models & Mechanisms

IS - 6

ER -