Age-dependent ERalpha MB1 splice variant expression in discrete areas of the human brain.

T.A. Ishunina; D.F. Swaab

doi:10.1016/j.neurobiolaging.2007.02.018

Age-dependent ERalpha MB1 splice variant expression in discrete areas of the human brain.

T.A. Ishunina, D.F. Swaab

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

A role of estrogens in brain aging and Alzheimer's disease (AD) is a hot topic of research. We show in material of 71 patients that the estrogen receptor alpha (ERalpha) splice variant MB1 is expressed at the protein and mRNA level in the human brain. MB1 is mainly confined to astrocytes, membranes and cytoplasm of projecting neurons and endothelial cells. It was consistently observed in the thalamus, colliculus inferior, pontine nuclei, dorsal motor nucleus of vagus, some motor neurons in the anterior and lateral horns of the spinal cord and rarely in pyramidal neurons of the cerebral cortex. The highest level of MB1 immunoreactivity (MB1-ir) was noted in the caudal hypothalamus, in particular in the tuberomamillary nucleus (TMN). MB1-ir in the TMN increased during aging in women. MB1-ir was higher in young (\

Original language	English
Pages (from-to)	1177-1189
Journal	Neurobiology of Aging
Volume	29
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.02.018
Publication status	Published - 2008

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title = "Age-dependent ERalpha MB1 splice variant expression in discrete areas of the human brain.",

abstract = "A role of estrogens in brain aging and Alzheimer's disease (AD) is a hot topic of research. We show in material of 71 patients that the estrogen receptor alpha (ERalpha) splice variant MB1 is expressed at the protein and mRNA level in the human brain. MB1 is mainly confined to astrocytes, membranes and cytoplasm of projecting neurons and endothelial cells. It was consistently observed in the thalamus, colliculus inferior, pontine nuclei, dorsal motor nucleus of vagus, some motor neurons in the anterior and lateral horns of the spinal cord and rarely in pyramidal neurons of the cerebral cortex. The highest level of MB1 immunoreactivity (MB1-ir) was noted in the caudal hypothalamus, in particular in the tuberomamillary nucleus (TMN). MB1-ir in the TMN increased during aging in women. MB1-ir was higher in young (\",

author = "T.A. Ishunina and D.F. Swaab",

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AB - A role of estrogens in brain aging and Alzheimer's disease (AD) is a hot topic of research. We show in material of 71 patients that the estrogen receptor alpha (ERalpha) splice variant MB1 is expressed at the protein and mRNA level in the human brain. MB1 is mainly confined to astrocytes, membranes and cytoplasm of projecting neurons and endothelial cells. It was consistently observed in the thalamus, colliculus inferior, pontine nuclei, dorsal motor nucleus of vagus, some motor neurons in the anterior and lateral horns of the spinal cord and rarely in pyramidal neurons of the cerebral cortex. The highest level of MB1 immunoreactivity (MB1-ir) was noted in the caudal hypothalamus, in particular in the tuberomamillary nucleus (TMN). MB1-ir in the TMN increased during aging in women. MB1-ir was higher in young (\

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