Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain

J. Guinea, F. Hagen, T. Pelaez, T. Boekhout, H. Tahoune, M. Torres-Narbona, E. Bouza

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    38 Citations (Scopus)

    Abstract

    We studied the serotypes, mating-types, AFLP genotypes, and antifungal susceptibility of 58 Cryptococcus neoformans strains causing 56 episodes of cryptococcosis in 55 patients over an 18-year period in a single institution. The underlying conditions of the patients were classified as HIV infection (n = 48) or non-HIV-related immunodeficiency (n = 7). Serotype A (n = 34; 58.9%) predominated, but serotype AD was involved in 23.2% of episodes. Most of the episodes were caused by mating-type a (n = 41; 73.2%) or alpha/a strains (n = 12; 21.5%). The most common genotype was AFLP1 (n = 26; 44.8%), followed by AFLP3 (n = 21; 36.2%), and AFLP2 (n = 11; 19.0%). In two different patients, we showed the coexistence of different serotypes and/or genotypes in the same episode (AFLP1 and 3). The new triazoles voriconazole, posaconazole and isavuconazole showed high and similar antifungal activity (MICs
    Original languageEnglish
    Pages (from-to)942-948
    JournalMedical Mycology
    Volume48
    Issue number7
    DOIs
    Publication statusPublished - 2010

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