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Aromatase changes in depression : A postmortem and animal experimental study. / Wu, Juan-Li; He, Yang; Hrubý, Radovan; Balesar, Rawien; Qi, Yang-Jian; Guo, Lei; Ren, Zhong; Zhu, Qiong-Bin; Huang, Man-Li; Swaab, Dick F; Bao, Ai-Min.

In: Psychoneuroendocrinology, Vol. 77, 05.01.2017, p. 56-62.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

Wu, J-L, He, Y, Hrubý, R, Balesar, R, Qi, Y-J, Guo, L, Ren, Z, Zhu, Q-B, Huang, M-L, Swaab, DF & Bao, A-M 2017, 'Aromatase changes in depression: A postmortem and animal experimental study' Psychoneuroendocrinology, vol. 77, pp. 56-62. DOI: 10.1016/j.psyneuen.2016.11.026

APA

Vancouver

Wu J-L, He Y, Hrubý R, Balesar R, Qi Y-J, Guo L et al. Aromatase changes in depression: A postmortem and animal experimental study. Psychoneuroendocrinology. 2017 Jan 5;77:56-62. Available from, DOI: 10.1016/j.psyneuen.2016.11.026

Author

Wu, Juan-Li ; He, Yang ; Hrubý, Radovan ; Balesar, Rawien ; Qi, Yang-Jian ; Guo, Lei ; Ren, Zhong ; Zhu, Qiong-Bin ; Huang, Man-Li ; Swaab, Dick F ; Bao, Ai-Min. / Aromatase changes in depression : A postmortem and animal experimental study. In: Psychoneuroendocrinology. 2017 ; Vol. 77. pp. 56-62

BibTeX

@article{1a9c9f988a914aa681753215c3d799fe,
title = "Aromatase changes in depression: A postmortem and animal experimental study",
abstract = "A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression. At first, aromatase immunoreactivity (ir) was quantified in the central part of the hypothalamic paraventricular nucleus (PVN) of 10 major depressive disorder (MDD) patients and 10 well-matched control subjects. Subsequently an animal experimental study was performed using the chronic unpredictable mild stress (CUMS) rats as depression model. The effect of administration of 1,4,6-androstatriene-3,17-dione (ATD), an aromatase inhibitor, was investigated by silastic capsule implantation. In the postmortem study, the amount of PVN aromatase-ir decreased significantly in the MDD group compared to the controls (P=0.029). In the animal study, ATD was found to cause significantly increased testosterone (T) levels, both in plasma and in the hypothalamus. However, ATD administration did not show significant effects on the depression-like behaviors or plasma corticosterone levels in CUMS rats. Based on our observations in human postmortem material and the animal experiment, we have to conclude that alterations in aromatase in adulthood do not seem to play a major role in the pathogenesis of the symptoms of depression.",
author = "Juan-Li Wu and Yang He and Radovan Hrub{\'y} and Rawien Balesar and Yang-Jian Qi and Lei Guo and Zhong Ren and Qiong-Bin Zhu and Man-Li Huang and Swaab, {Dick F} and Ai-Min Bao",
note = "Copyright {\circledC} 2016 Elsevier Ltd. All rights reserved.",
year = "2017",
month = "1",
day = "5",
doi = "10.1016/j.psyneuen.2016.11.026",
language = "English",
volume = "77",
pages = "56--62",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Aromatase changes in depression

T2 - Psychoneuroendocrinology

AU - Wu,Juan-Li

AU - He,Yang

AU - Hrubý,Radovan

AU - Balesar,Rawien

AU - Qi,Yang-Jian

AU - Guo,Lei

AU - Ren,Zhong

AU - Zhu,Qiong-Bin

AU - Huang,Man-Li

AU - Swaab,Dick F

AU - Bao,Ai-Min

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2017/1/5

Y1 - 2017/1/5

N2 - A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression. At first, aromatase immunoreactivity (ir) was quantified in the central part of the hypothalamic paraventricular nucleus (PVN) of 10 major depressive disorder (MDD) patients and 10 well-matched control subjects. Subsequently an animal experimental study was performed using the chronic unpredictable mild stress (CUMS) rats as depression model. The effect of administration of 1,4,6-androstatriene-3,17-dione (ATD), an aromatase inhibitor, was investigated by silastic capsule implantation. In the postmortem study, the amount of PVN aromatase-ir decreased significantly in the MDD group compared to the controls (P=0.029). In the animal study, ATD was found to cause significantly increased testosterone (T) levels, both in plasma and in the hypothalamus. However, ATD administration did not show significant effects on the depression-like behaviors or plasma corticosterone levels in CUMS rats. Based on our observations in human postmortem material and the animal experiment, we have to conclude that alterations in aromatase in adulthood do not seem to play a major role in the pathogenesis of the symptoms of depression.

AB - A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression. At first, aromatase immunoreactivity (ir) was quantified in the central part of the hypothalamic paraventricular nucleus (PVN) of 10 major depressive disorder (MDD) patients and 10 well-matched control subjects. Subsequently an animal experimental study was performed using the chronic unpredictable mild stress (CUMS) rats as depression model. The effect of administration of 1,4,6-androstatriene-3,17-dione (ATD), an aromatase inhibitor, was investigated by silastic capsule implantation. In the postmortem study, the amount of PVN aromatase-ir decreased significantly in the MDD group compared to the controls (P=0.029). In the animal study, ATD was found to cause significantly increased testosterone (T) levels, both in plasma and in the hypothalamus. However, ATD administration did not show significant effects on the depression-like behaviors or plasma corticosterone levels in CUMS rats. Based on our observations in human postmortem material and the animal experiment, we have to conclude that alterations in aromatase in adulthood do not seem to play a major role in the pathogenesis of the symptoms of depression.

U2 - 10.1016/j.psyneuen.2016.11.026

DO - 10.1016/j.psyneuen.2016.11.026

M3 - Article

VL - 77

SP - 56

EP - 62

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 2891618