Aspergillus felis sp nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs

Vanessa R. Barrs, Tineke M. van Doorn, Jos Houbraken, Sarah E. Kidd, Patricia Martin, Maria Dolores Pinheiro, Malcolm Richardson, Janos Varga, Robert A. Samson

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    89 Citations (Scopus)

    Abstract

    We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro. © 2013 Barrs et al.
    Original languageEnglish
    Article numbere64871
    JournalPLoS One
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 14 Jun 2013

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