Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens, Jop Kind

Research output: Contribution to journal/periodicalBook/Film/Article reviewScientific

Abstract

A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume70
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Animals
  • Cell Nucleus
  • Chromatin
  • Genome
  • Intermediate Filaments
  • Nuclear Envelope
  • Nuclear Lamina

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