Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens; Jop Kind

doi:10.1016/j.ceb.2020.11.006

Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Pim M J Rullens, Jop Kind

Hubrecht Institute

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

14 Citations (Scopus)

Abstract

A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	70
DOIs	https://doi.org/10.1016/j.ceb.2020.11.006
Publication status	Published - Jun 2021

Keywords

Animals
Cell Nucleus
Chromatin
Genome
Intermediate Filaments
Nuclear Envelope
Nuclear Lamina

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10.1016/j.ceb.2020.11.006

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title = "Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome",

abstract = "A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.",

keywords = "Animals, Cell Nucleus, Chromatin, Genome, Intermediate Filaments, Nuclear Envelope, Nuclear Lamina",

author = "Rullens, {Pim M J} and Jop Kind",

year = "2021",

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doi = "10.1016/j.ceb.2020.11.006",

language = "English",

volume = "70",

pages = "51--57",

journal = "Current Opinion in Cell Biology",

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T1 - Attach and stretch

T2 - Emerging roles for genome-lamina contacts in shaping the 3D genome

AU - Rullens, Pim M J

AU - Kind, Jop

PY - 2021/6

Y1 - 2021/6

N2 - A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

AB - A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Lamina-associated domains are believed to contribute to the regulation of gene transcription and to provide structural three-dimensional support to the organization of the genome in A and B compartments and topologically associating domains. In this review, we will evaluate recent work addressing the role of lamina-associated domains in three-dimensional genome organization and propose experimental frameworks that may expand our understanding of their interdependence.

KW - Animals

KW - Cell Nucleus

KW - Chromatin

KW - Genome

KW - Intermediate Filaments

KW - Nuclear Envelope

KW - Nuclear Lamina

U2 - 10.1016/j.ceb.2020.11.006

DO - 10.1016/j.ceb.2020.11.006

M3 - Book/Film/Article review

C2 - 33360765

SN - 0955-0674

VL - 70

SP - 51

EP - 57

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Attach and stretch: Emerging roles for genome-lamina contacts in shaping the 3D genome

Abstract

Keywords

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