Attachment issues: kinetochore transformations and spindle checkpoint silencing

Banafsheh Etemad, Geert Jpl Kops

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetochores of all chromosomes are established. The anaphase inhibitor is generated at unattached kinetochores and inhibitor production is prevented when microtubules are captured. Understanding the molecular changes in the kinetochore that are evoked by microtubule attachments is crucial for understanding the mechanisms of SAC signaling and silencing. Here, we highlight the most recent findings on these events, pinpoint some remaining mysteries, and argue for incorporating holistic views of kinetochore dynamics in order to understand SAC silencing.

Original languageEnglish
Pages (from-to)101-8
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume39
DOIs
Publication statusPublished - Apr 2016

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