Beyond growth signaling: Paneth cells metabolically support ISCs

Talya L Dayton, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.

Original languageEnglish
Pages (from-to)851-852
Number of pages2
JournalCell Research
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Journal Article

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