Bilateral population receptive fields in congenital hemihydranencephaly: Ophthalmic and Physiological Optics

A. Fracasso, Y. Koenraads, G. L. Porro, Serge O. Dumoulin

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Purpose: Congenital hemihydranencephaly (HH) is a very rare disorder characterised by prenatal near-complete unilateral loss of the cerebral cortex. We investigated a patient affected by congenital right HH whose visual field extended significantly into the both visual hemifields, suggesting a reorganisation of the remaining left visual hemisphere. We examined the early visual cortex reorganisation using functional MRI (7T) and population receptive field (pRF) modelling. Methods: Data were acquired by means of a 7T MRI while the patient affected by HH viewed conventional population receptive field mapping stimuli. Two possible pRF reorganisation schemes were evaluated: where every cortical location processed information from either (i) a single region of the visual field or (ii) from two bilateral regions of the visual field. Results: In the patient affected by HH, bilateral pRFs in single cortical locations of the remaining hemisphere were found. In addition, using this specific pRF reorganisation scheme, the biologically known relationship between pRF size and eccentricity was found. Conclusions: Bilateral pRFs were found in the remaining left hemisphere of the patient affected by HH, indicating reorganisation of intra-cortical wiring of the early visual cortex and confirming brain plasticity and reorganisation after an early cerebral damage in humans.
Original languageEnglish
Pages (from-to)324-334
Number of pages11
JournalOphthalmic and Physiological Optics
Volume36
Issue number3
DOIs
Publication statusPublished - 25 Apr 2016

Keywords

  • functional MRI hemihydranencephaly modelling plasticity population receptive field stability human visual-cortex macaque monkey projection tomography extrastriate cortex cebus monkey representation maps fmri topography plasticity

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