Black Molds and Melanized Yeasts Pathogenic to Humans

Anuradha Chowdhary, John Perfect, G Sybren de Hoog

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    Abstract

    A review is given of melanized fungi involved in human infection, including species forming budding cells and strictly filamentous representatives. Classically, they are known as "phaeoid" or "dematiaceous" fungi, and, today, agents are recognized to belong to seven orders of fungi, of which the Chaetothyriales and Pleosporales are the most important. Infections range from cutaneous or pulmonary colonization to systemic or disseminated invasion. Subcutaneous involvement, either primary or after dissemination, may lead to host tissue proliferation of dermis or epidermis. Particularly in the Chaetothyriales, subcutaneous and systemic infections may occur in otherwise apparently healthy individuals. Infections are mostly chronic and require extended antifungal therapy and/or surgery.

    Original languageEnglish
    JournalCold Spring Harbor Perpectives in Medicine
    DOIs
    Publication statusPublished - 10 Nov 2014

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