Building bridges between fields: bringing together development and homeostasis

Sonja D C Weterings; Marek J van Oostrom; Katharina F Sonnen

doi:10.1242/dev.193268

Building bridges between fields: bringing together development and homeostasis

Sonja D C Weterings, Marek J van Oostrom, Katharina F Sonnen

Hubrecht Institute

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

5 Citations (Scopus)

Abstract

Despite striking parallels between the fields of developmental biology and adult tissue homeostasis, these are disconnected in contemporary research. Although development describes tissue generation and homeostasis describes tissue maintenance, it is the balance between stem cell proliferation and differentiation that coordinates both processes. Upstream signalling regulates this balance to achieve the required outcome at the population level. Both development and homeostasis require tight regulation of stem cells at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields.

Original language	English
Journal	Development (Cambridge)
Volume	148
Issue number	14
DOIs	https://doi.org/10.1242/dev.193268
Publication status	Published - 15 Jul 2021

Keywords

Animals
Cell Differentiation/physiology
Cell Proliferation
Drosophila
Embryonic Development
Homeostasis
Humans
Models, Biological
Signal Transduction
Stem Cells

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10.1242/dev.193268

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title = "Building bridges between fields: bringing together development and homeostasis",

abstract = "Despite striking parallels between the fields of developmental biology and adult tissue homeostasis, these are disconnected in contemporary research. Although development describes tissue generation and homeostasis describes tissue maintenance, it is the balance between stem cell proliferation and differentiation that coordinates both processes. Upstream signalling regulates this balance to achieve the required outcome at the population level. Both development and homeostasis require tight regulation of stem cells at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields.",

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T1 - Building bridges between fields

T2 - bringing together development and homeostasis

AU - Weterings, Sonja D C

AU - van Oostrom, Marek J

AU - Sonnen, Katharina F

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Despite striking parallels between the fields of developmental biology and adult tissue homeostasis, these are disconnected in contemporary research. Although development describes tissue generation and homeostasis describes tissue maintenance, it is the balance between stem cell proliferation and differentiation that coordinates both processes. Upstream signalling regulates this balance to achieve the required outcome at the population level. Both development and homeostasis require tight regulation of stem cells at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields.

AB - Despite striking parallels between the fields of developmental biology and adult tissue homeostasis, these are disconnected in contemporary research. Although development describes tissue generation and homeostasis describes tissue maintenance, it is the balance between stem cell proliferation and differentiation that coordinates both processes. Upstream signalling regulates this balance to achieve the required outcome at the population level. Both development and homeostasis require tight regulation of stem cells at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields.

KW - Animals

KW - Cell Differentiation/physiology

KW - Cell Proliferation

KW - Drosophila

KW - Embryonic Development

KW - Homeostasis

KW - Humans

KW - Models, Biological

KW - Signal Transduction

KW - Stem Cells

U2 - 10.1242/dev.193268

DO - 10.1242/dev.193268

M3 - Book/Film/Article review

C2 - 34279592

SN - 0950-1991

VL - 148

JO - Development (Cambridge)

JF - Development (Cambridge)

IS - 14

ER -

Building bridges between fields: bringing together development and homeostasis

Abstract

Keywords

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