Caffeine has no effect on eyeblink conditioning in mice

Anders Rasmussen; Anna C H G IJpelaar; Chris I De Zeeuw; Henk-Jan Boele

doi:10.1016/j.bbr.2017.09.013

Caffeine has no effect on eyeblink conditioning in mice

Anders Rasmussen, Anna C H G IJpelaar, Chris I De Zeeuw, Henk-Jan Boele

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

4 Citations (Scopus)

Abstract

Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.

Original language	English
Pages (from-to)	252-255
Journal	Behavioural Brain Research
Volume	337
DOIs	https://doi.org/10.1016/j.bbr.2017.09.013
Publication status	Published - 02 Jan 2018

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Journal Article

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10.1016/j.bbr.2017.09.013

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title = "Caffeine has no effect on eyeblink conditioning in mice",

abstract = "Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.",

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T1 - Caffeine has no effect on eyeblink conditioning in mice

AU - Rasmussen, Anders

AU - IJpelaar, Anna C H G

AU - De Zeeuw, Chris I

AU - Boele, Henk-Jan

PY - 2018/1/2

Y1 - 2018/1/2

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AB - Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice. The results show that, at the dosages we used, caffeine affects neither the rate of acquisition, nor the timing of the onset or peak of the conditioned blink responses. Therefore, we conclude that caffeine neither improves nor worsens performance on eyeblink conditioning.

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JO - Behavioural Brain Research

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ER -

Caffeine has no effect on eyeblink conditioning in mice

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