Cardiac regenerative capacity: an evolutionary afterthought?

TY - JOUR

T1 - Cardiac regenerative capacity

T2 - an evolutionary afterthought?

AU - Nguyen, Phong D

AU - de Bakker, Dennis E M

AU - Bakkers, Jeroen

PY - 2021/6

Y1 - 2021/6

N2 - Cardiac regeneration is the outcome of the highly regulated interplay of multiple processes, including the inflammatory response, cardiomyocyte dedifferentiation and proliferation, neovascularization and extracellular matrix turnover. Species-specific traits affect these injury-induced processes, resulting in a wide variety of cardiac regenerative potential between species. Indeed, while mammals are generally considered poor regenerators, certain amphibian and fish species like the zebrafish display robust regenerative capacity post heart injury. The species-specific traits underlying these differential injury responses are poorly understood. In this review, we will compare the injury induced processes of the mammalian and zebrafish heart, describing where these processes overlap and diverge. Additionally, by examining multiple species across the animal kingdom, we will highlight particular traits that either positively or negatively affect heart regeneration. Last, we will discuss the possibility of overcoming regeneration-limiting traits to induce heart regeneration in mammals.

AB - Cardiac regeneration is the outcome of the highly regulated interplay of multiple processes, including the inflammatory response, cardiomyocyte dedifferentiation and proliferation, neovascularization and extracellular matrix turnover. Species-specific traits affect these injury-induced processes, resulting in a wide variety of cardiac regenerative potential between species. Indeed, while mammals are generally considered poor regenerators, certain amphibian and fish species like the zebrafish display robust regenerative capacity post heart injury. The species-specific traits underlying these differential injury responses are poorly understood. In this review, we will compare the injury induced processes of the mammalian and zebrafish heart, describing where these processes overlap and diverge. Additionally, by examining multiple species across the animal kingdom, we will highlight particular traits that either positively or negatively affect heart regeneration. Last, we will discuss the possibility of overcoming regeneration-limiting traits to induce heart regeneration in mammals.

KW - Animals

KW - Biological Evolution

KW - Heart/embryology

KW - Heart Diseases/therapy

KW - Humans

KW - Myocytes, Cardiac/cytology

KW - Regeneration

U2 - 10.1007/s00018-021-03831-9

DO - 10.1007/s00018-021-03831-9

M3 - Book/Film/Article review

C2 - 33950316

SN - 1420-682X

VL - 78

SP - 5107

EP - 5122

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 12

ER -