Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

B.M. Hogan; F.L. Bos; J. Bussmann; M. de Witte; N.C. Chi; H.J. Duckers; S. Schulte-Merker

doi:10.1038/ng.321

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

B.M. Hogan, F.L. Bos, J. Bussmann, M. de Witte, N.C. Chi, H.J. Duckers, S. Schulte-Merker

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

342 Citations (Scopus)

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Original language	English
Pages (from-to)	396-398
Journal	Nature Genetics
Volume	41
Issue number	4
DOIs	https://doi.org/10.1038/ng.321
Publication status	Published - 2009

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title = "Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting",

abstract = "Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.",

author = "B.M. Hogan and F.L. Bos and J. Bussmann and {de Witte}, M. and N.C. Chi and H.J. Duckers and S. Schulte-Merker",

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AU - Hogan, B.M.

AU - Bos, F.L.

AU - Bussmann, J.

AU - de Witte, M.

AU - Chi, N.C.

AU - Duckers, H.J.

AU - Schulte-Merker, S.

N1 - Reporting year: 2009 Metis note: ng.321

PY - 2009

Y1 - 2009

N2 - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

AB - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

U2 - 10.1038/ng.321

DO - 10.1038/ng.321

M3 - Article

SN - 1061-4036

VL - 41

SP - 396

EP - 398

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Abstract

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