Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

B.M. Hogan, F.L. Bos, J. Bussmann, M. de Witte, N.C. Chi, H.J. Duckers, S. Schulte-Merker

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Original languageEnglish
Pages (from-to)396-398
JournalNature Genetics
Volume41
Issue number4
DOIs
Publication statusPublished - 2009

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