Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder

Saša Peter, Chris I De Zeeuw, Tobias M Boeckers, Michael J Schmeisser

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component. To date, several hundred different genetic mutations have been identified to play a role in its aetiology. The heterogeneity of genetic abnormalities combined with the different brain regions where aberrations are found makes the search for causative mechanisms a daunting task. Even within a limited number of brain regions, a myriad of different neural circuit dysfunctions may lead to ASD. Here, we review mouse models that incorporate mutations of ASD risk genes causing pathologies in the cerebellum and striatum and highlight the vulnerability of related circuit dysfunctions within these brain regions in ASD pathophysiology.

Original languageEnglish
Pages (from-to)103-119
Number of pages17
JournalAdvances in anatomy, embryology, and cell biology
Volume224
DOIs
Publication statusPublished - 2017

Keywords

  • Journal Article

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