Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba

H. Badali, M. Fernandez-Gonzalez, B. Mousavi, M.T. Illnait-Zaragozi, J.C. Gonzalez-Rodriguez, G.S. de Hoog, J.F.G.M. Meis

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    Abstract

    We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 mug/ml), fluconazole (>64 mug/ml), anidulafungin (8 mug/ml) and caspofungin (8 mug/ml) were found.
    Original languageEnglish
    Pages (from-to)439-444
    JournalMycopathologia
    Volume175
    Issue number5-6
    DOIs
    Publication statusPublished - Jun 2013

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