Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study

Welmoed A Krudop, Sjanne Bosman, Jeroen J G Geurts, Sietske A M Sikkes, Nicolaas A Verwey, Max L Stek, Philip Scheltens, Annemieke J M Rozemuller, Yolande A L Pijnenburg,

Research output: Contribution to journal/periodicalArticleScientificpeer-review


AIMS: A clinical frontal lobe syndrome (FLS) is generally attributed to functional or structural disturbances within frontal-subcortical circuits. We studied the distribution of pathological brain changes in FLS. Additionally, the prevalence of FLS among various disorders was studied.

METHODS: We systematically screened clinical files of donors to the Netherlands Brain Bank (n = 2,814) for FLS. A total of 262 FLS cases were identified, and the distribution of postmortem pathological changes within the frontal-subcortical circuits was extracted from their neuropathological reports.

RESULTS: In 244 out of 262 patients (93%), pathological changes within the frontal-subcortical circuits were found: 90 subjects (34%) with frontal cortical pathology and 18 (7%) with pathology restricted to subcortical grey matter nuclei, whereas 136 subjects (52%) showed both cortical and subcortical pathology. In 18 subjects (7%), no pathology was found in the examined areas. The prevalence of FLS was highest in frontal-temporal lobar degeneration, followed by progressive supranuclear palsy and vascular dementia [χ(2)(6, n = 1,561) = 222.64, p < 0.01].

CONCLUSION: In this large brain bank study, the distribution of pathological changes in subjects with FLS was shown to be frontal-subcortical for the first time. A minority of FLS cases had pathology in the subcortical regions only or no frontal pathology at all.

Original languageEnglish
Pages (from-to)121-9
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number3-4
Publication statusPublished - 2015


  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Autopsy
  • Female
  • Frontal Lobe
  • Frontotemporal Dementia
  • Humans
  • Male
  • Middle Aged
  • Netherlands
  • Neurodegenerative Diseases
  • Retrospective Studies
  • Tissue Banks


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