Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population - an emerging outbreak in Australia

Fabian Carriconde, Félix Gilgado, Ian Arthur, David Ellis, Richard Malik, Nathalie van de Wiele, Vincent Robert, Bart J. Currie, Wieland Meyer

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    65 Citations (Scopus)

    Abstract

    Cryptococcus gattii is a basidiomycetous yeast that causes life-threatening disease in humans and animals. Within C. gattii, four molecular types are recognized (VGI to VGIV). The Australian VGII population has been in the spotlight since 2005, when it was suggested as the possible origin for the ongoing outbreak at Vancouver Island (British Columbia, Canada), with same-sex mating being suggested as the driving force behind the emergence of this outbreak, and is nowadays hypothesized as a widespread phenomenon in C. gattii. However, an in-depth characterization of the Australian VGII population is still lacking. The present work aimed to define the genetic variability within the Australian VGII population and determine processes shaping its population structure.
    Original languageEnglish
    Article numbere16936
    JournalPLoS One
    Volume6
    Issue number2
    DOIs
    Publication statusPublished - 2011

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