Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population - an emerging outbreak in Australia

Fabian Carriconde; Félix Gilgado; Ian Arthur; David Ellis; Richard Malik; Nathalie van de Wiele; Vincent Robert; Bart J. Currie; Wieland Meyer

doi:10.1371/journal.pone.0016936

Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population - an emerging outbreak in Australia

Fabian Carriconde, Félix Gilgado, Ian Arthur, David Ellis, Richard Malik, Nathalie van de Wiele, Vincent Robert, Bart J. Currie, Wieland Meyer

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

71 Citations (Scopus)

Abstract

Cryptococcus gattii is a basidiomycetous yeast that causes life-threatening disease in humans and animals. Within C. gattii, four molecular types are recognized (VGI to VGIV). The Australian VGII population has been in the spotlight since 2005, when it was suggested as the possible origin for the ongoing outbreak at Vancouver Island (British Columbia, Canada), with same-sex mating being suggested as the driving force behind the emergence of this outbreak, and is nowadays hypothesized as a widespread phenomenon in C. gattii. However, an in-depth characterization of the Australian VGII population is still lacking. The present work aimed to define the genetic variability within the Australian VGII population and determine processes shaping its population structure.

Original language	English
Article number	e16936
Journal	PLoS One
Volume	6
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0016936 https://doi.org/10.1371/journal.pone.0016936
Publication status	Published - 2011

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Carriconde, F., Gilgado, F., Arthur, I., Ellis, D., Malik, R., van de Wiele, N., Robert, V., Currie, B. J., & Meyer, W. (2011). Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population - an emerging outbreak in Australia. PLoS One, 6(2), Article e16936. https://doi.org/10.1371/journal.pone.0016936, https://doi.org/10.1371/journal.pone.0016936

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AU - Carriconde, Fabian

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AU - Ellis, David

AU - Malik, Richard

AU - van de Wiele, Nathalie

AU - Robert, Vincent

AU - Currie, Bart J.

AU - Meyer, Wieland

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AB - Cryptococcus gattii is a basidiomycetous yeast that causes life-threatening disease in humans and animals. Within C. gattii, four molecular types are recognized (VGI to VGIV). The Australian VGII population has been in the spotlight since 2005, when it was suggested as the possible origin for the ongoing outbreak at Vancouver Island (British Columbia, Canada), with same-sex mating being suggested as the driving force behind the emergence of this outbreak, and is nowadays hypothesized as a widespread phenomenon in C. gattii. However, an in-depth characterization of the Australian VGII population is still lacking. The present work aimed to define the genetic variability within the Australian VGII population and determine processes shaping its population structure.

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DO - 10.1371/journal.pone.0016936

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JO - PLoS One

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Clonality and α-a recombination in the Australian Cryptococcus gattii VGII population - an emerging outbreak in Australia

Abstract

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