CNVs are associated with genomic architecture in a songbird

Vinicius H. da Silva; Veronika N. Laine; M Bosse; Kees van Oers; B.W. Dibbits; Marcel E. Visser; Richard P. M. A. Crooijmans; Martien A.M.  Groenen

doi:10.1186/s12864-018-4577-1

CNVs are associated with genomic architecture in a songbird

Vinicius H. da Silva (Corresponding author), Veronika N. Laine, M Bosse, Kees van Oers, B.W. Dibbits, Marcel E. Visser, Richard P. M. A. Crooijmans, Martien A.M. Groenen

NIOO - Animal Ecology (AnE)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

Understanding variation in genome structure is essential to understand phenotypic differences within populations and the evolutionary history of species. A promising form of this structural variation is copy number variation (CNV). CNVs can be generated by different recombination mechanisms, such as non-allelic homologous recombination, that rely on specific characteristics of the genome architecture. These structural variants can therefore be more abundant at particular genes ultimately leading to variation in phenotypes under selection. Detailed characterization of CNVs therefore can reveal evolutionary footprints of selection and provide insight in their contribution to phenotypic variation in wild populations.

Original language	English
Article number	195
Journal	BMC Genomics
Volume	19
Issue number	2
DOIs	https://doi.org/10.1186/s12864-018-4577-1
Publication status	Published - 2018

Keywords

national

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10.1186/s12864-018-4577-1Licence: CC BY

6503_daSilvaFinal published version, 1.27 MBLicence: CC BY

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title = "CNVs are associated with genomic architecture in a songbird",

abstract = "Understanding variation in genome structure is essential to understand phenotypic differences within populations and the evolutionary history of species. A promising form of this structural variation is copy number variation (CNV). CNVs can be generated by different recombination mechanisms, such as non-allelic homologous recombination, that rely on specific characteristics of the genome architecture. These structural variants can therefore be more abundant at particular genes ultimately leading to variation in phenotypes under selection. Detailed characterization of CNVs therefore can reveal evolutionary footprints of selection and provide insight in their contribution to phenotypic variation in wild populations.",

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TY - JOUR

T1 - CNVs are associated with genomic architecture in a songbird

AU - da Silva, Vinicius H.

AU - Laine, Veronika N.

AU - Bosse, M

AU - Oers, Kees van

AU - Dibbits, B.W.

AU - Visser, Marcel E.

AU - M. A. Crooijmans, Richard P.

AU - Groenen, Martien A.M.

N1 - 6503, AnE; Data Archiving: data archived at publisher's and at NCBI https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE105131

PY - 2018

Y1 - 2018

N2 - Understanding variation in genome structure is essential to understand phenotypic differences within populations and the evolutionary history of species. A promising form of this structural variation is copy number variation (CNV). CNVs can be generated by different recombination mechanisms, such as non-allelic homologous recombination, that rely on specific characteristics of the genome architecture. These structural variants can therefore be more abundant at particular genes ultimately leading to variation in phenotypes under selection. Detailed characterization of CNVs therefore can reveal evolutionary footprints of selection and provide insight in their contribution to phenotypic variation in wild populations.

AB - Understanding variation in genome structure is essential to understand phenotypic differences within populations and the evolutionary history of species. A promising form of this structural variation is copy number variation (CNV). CNVs can be generated by different recombination mechanisms, such as non-allelic homologous recombination, that rely on specific characteristics of the genome architecture. These structural variants can therefore be more abundant at particular genes ultimately leading to variation in phenotypes under selection. Detailed characterization of CNVs therefore can reveal evolutionary footprints of selection and provide insight in their contribution to phenotypic variation in wild populations.

KW - national

UR - https://www.ncbi.nlm.nih.gov/bioproject/PRJNA415009

U2 - 10.1186/s12864-018-4577-1

DO - 10.1186/s12864-018-4577-1

M3 - Article

SN - 1471-2164

VL - 19

JO - BMC Genomics

JF - BMC Genomics

IS - 2

M1 - 195

ER -

CNVs are associated with genomic architecture in a songbird

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Affymetrix SNP array data for wild Dutch great tits (Parus major) (Great Tit)

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CNVs are associated with genomic architecture in a songbird

Abstract

Keywords

Access to Document

Other files and links

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Datasets

Affymetrix SNP array data for wild Dutch great tits (Parus major) (Great Tit)

Cite this