Combination of amphotericin b and terbinafine against melanized fungi associated with chromoblastomycosis

S. Deng, W. Lei, G. S. de Hoog, L. Yang, R. G. Vitale, H. Rafati, M. Seyedmousavi, A. Tolooe, H. van der Lee, W. Liao, P. E. Verweij, S. Seyedmousavi

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number6
DOIs
Publication statusPublished - 01 Jun 2018

Keywords

  • Amphotericin B
  • Chromoblastomycosis
  • Combination therapy
  • Melanized fungi
  • Terbinafine

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