Abstract
Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .
Original language | English |
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Journal | Antimicrobial Agents and Chemotherapy |
Volume | 62 |
Issue number | 6 |
DOIs | |
Publication status | Published - 01 Jun 2018 |
Keywords
- Amphotericin B
- Chromoblastomycosis
- Combination therapy
- Melanized fungi
- Terbinafine