Combining Brain Perturbation and Neuroimaging in Non-human Primates

P Christiaan Klink, Jean-François Aubry, Vincent P Ferrera, Andrew S Fox, Sean Froudist-Walsh, Bechir Jarraya, Elisa Konofagou, Richard Krauzlis, Adam Messinger, Anna S Mitchell, Michael Ortiz-Rios, Hiroyuki Oya, Angela C Roberts, Anna Wang Roe, Matthew F S Rushworth, Jérôme Sallet, Michael Christoph Schmid, Charles E Schroeder, Jordy Tasserie, Doris TsaoLynn Uhrig, Wim Vanduffel, Melanie Wilke, Igor Kagan, Christopher I Petkov

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.

Original languageEnglish
Pages (from-to)118017
JournalNeuroImage
DOIs
Publication statusE-pub ahead of print - Mar 2021

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