TY - JOUR
T1 - Combining Brain Perturbation and Neuroimaging in Non-human Primates
AU - Klink, P Christiaan
AU - Aubry, Jean-François
AU - Ferrera, Vincent P
AU - Fox, Andrew S
AU - Froudist-Walsh, Sean
AU - Jarraya, Bechir
AU - Konofagou, Elisa
AU - Krauzlis, Richard
AU - Messinger, Adam
AU - Mitchell, Anna S
AU - Ortiz-Rios, Michael
AU - Oya, Hiroyuki
AU - Roberts, Angela C
AU - Roe, Anna Wang
AU - Rushworth, Matthew F S
AU - Sallet, Jérôme
AU - Schmid, Michael Christoph
AU - Schroeder, Charles E
AU - Tasserie, Jordy
AU - Tsao, Doris
AU - Uhrig, Lynn
AU - Vanduffel, Wim
AU - Wilke, Melanie
AU - Kagan, Igor
AU - Petkov, Christopher I
N1 - Copyright © 2021. Published by Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.
AB - Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.
U2 - 10.1016/j.neuroimage.2021.118017
DO - 10.1016/j.neuroimage.2021.118017
M3 - Article
C2 - 33794355
SP - 118017
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -