Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings, Bert Gerrits van den Ende, Mirthe W J Raats, Ahmed Hassan Fahal, Wendy W J van de Sande, Ferry Hagen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

Original languageEnglish
Pages (from-to)6
JournalMycopathologia
Volume189
Issue number1
DOIs
Publication statusPublished - 17 Jan 2024

Keywords

  • Itraconazole/pharmacology
  • Mycetoma
  • Azoles
  • Madurella

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