Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings; Bert Gerrits van den Ende; Mirthe W J Raats; Ahmed Hassan Fahal; Wendy W J van de Sande; Ferry Hagen

doi:10.1007/s11046-023-00807-0

Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Mickey Konings, Bert Gerrits van den Ende, Mirthe W J Raats, Ahmed Hassan Fahal, Wendy W J van de Sande, Ferry Hagen

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

Original language	English
Pages (from-to)	6
Journal	Mycopathologia
Volume	189
Issue number	1
DOIs	https://doi.org/10.1007/s11046-023-00807-0
Publication status	Published - 17 Jan 2024

Keywords

Itraconazole/pharmacology
Mycetoma
Azoles
Madurella

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10.1007/s11046-023-00807-0

https://link.springer.com/article/10.1007/s11046-023-00807-0

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title = "Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176",

abstract = "Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.",

keywords = "Itraconazole/pharmacology, Mycetoma, Azoles, Madurella",

author = "Mickey Konings and {Gerrits van den Ende}, Bert and Raats, {Mirthe W J} and Fahal, {Ahmed Hassan} and {van de Sande}, {Wendy W J} and Ferry Hagen",

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AU - Konings, Mickey

AU - Gerrits van den Ende, Bert

AU - Raats, Mirthe W J

AU - Fahal, Ahmed Hassan

AU - van de Sande, Wendy W J

AU - Hagen, Ferry

PY - 2024/1/17

Y1 - 2024/1/17

N2 - Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

AB - Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

KW - Itraconazole/pharmacology

KW - Mycetoma

KW - Azoles

KW - Madurella

U2 - 10.1007/s11046-023-00807-0

DO - 10.1007/s11046-023-00807-0

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VL - 189

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JO - Mycopathologia

JF - Mycopathologia

IS - 1

ER -

Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176

Abstract

Keywords

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