Conditioned climbing fiber responses in cerebellar cortex and nuclei

Michiel M Ten Brinke; H.J. Boele; C I De Zeeuw

doi:10.1016/j.neulet.2018.04.035

Conditioned climbing fiber responses in cerebellar cortex and nuclei

Michiel M Ten Brinke
, H.J. Boele
, C I De Zeeuw

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

29 Citations (Scopus)

Abstract

The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.

Original language	English
Pages (from-to)	26-36
Journal	Neuroscience Letters
Volume	688
DOIs	https://doi.org/10.1016/j.neulet.2018.04.035
Publication status	Published - 2019

Keywords

Journal Article
Review

Access to Document

10.1016/j.neulet.2018.04.035

Cite this

@article{1cdfdfba74ae4e43a1cf461a3240c159,

title = "Conditioned climbing fiber responses in cerebellar cortex and nuclei",

abstract = "The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.",

keywords = "Journal Article, Review",

author = "\{Ten Brinke\}, \{Michiel M\} and H.J. Boele and \{De Zeeuw\}, \{C I\}",

note = "Copyright {\textcopyright} 2018. Published by Elsevier B.V.",

year = "2019",

doi = "10.1016/j.neulet.2018.04.035",

language = "English",

volume = "688",

pages = "26--36",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Conditioned climbing fiber responses in cerebellar cortex and nuclei

AU - Ten Brinke, Michiel M

AU - Boele, H.J.

AU - De Zeeuw, C I

PY - 2019

Y1 - 2019

N2 - The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.

AB - The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.

KW - Journal Article

KW - Review

U2 - 10.1016/j.neulet.2018.04.035

DO - 10.1016/j.neulet.2018.04.035

M3 - Article

C2 - 29689340

SN - 0304-3940

VL - 688

SP - 26

EP - 36

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Conditioned climbing fiber responses in cerebellar cortex and nuclei

Abstract

Keywords

Access to Document

Fingerprint

Cite this