Controlling miRNA regulation in disease

W.M. Gommans; E. Berezikov

doi:10.1007/978-1-61779-427-8_1

Controlling miRNA regulation in disease

W.M. Gommans, E. Berezikov

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

33 Citations (Scopus)

Abstract

Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype. KEYWORDS: Animals; Disease/genetics; Gene Expression Regulation; Humans; MicroRNAs/ genetics/ metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics/metabolism

Original language	English
Pages (from-to)	1-18
Journal	Methods in Molecular Biology
Volume	822
DOIs	https://doi.org/10.1007/978-1-61779-427-8_1
Publication status	Published - 2012

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title = "Controlling miRNA regulation in disease",

abstract = "Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype. KEYWORDS: Animals; Disease/genetics; Gene Expression Regulation; Humans; MicroRNAs/ genetics/ metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics/metabolism",

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AB - Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype. KEYWORDS: Animals; Disease/genetics; Gene Expression Regulation; Humans; MicroRNAs/ genetics/ metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger/genetics/metabolism

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Controlling miRNA regulation in disease

Abstract

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