Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

Kerstin Schneeberger, Bart Spee, Pedro Costa, Norman Sachs, Hans Clevers, Jos Malda

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Adult tissue stem cells can form self-organizing 3D organoids in vitro. Organoids resemble small units of their organ of origin and have great potential for tissue engineering, as well as models of disease. However, current culture technology limits the size, architecture and complexity of organoids. Here, we review the establishment of intestinal and hepatic organoids and discuss how the convergence of organoids and biofabrication technologies can help overcome current limitations, and thereby further advance the translational application of organoids in tissue engineering and regenerative medicine.

Original languageEnglish
Pages (from-to)013001
JournalBiofabrication
Volume9
Issue number1
DOIs
Publication statusPublished - 06 Mar 2017

Keywords

  • Extracellular Matrix
  • Humans
  • Intestines
  • Liver
  • Organoids
  • Regeneration
  • Regenerative Medicine
  • Stem Cells
  • Tissue Engineering
  • Tissue Scaffolds
  • Journal Article
  • Review

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