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Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. / Hamada, Mustafa S; Goethals, Sarah; de Vries, Sharon I; Brette, Romain; Kole, M.H.P.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, 19.12.2016, p. 14841-14846.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

Hamada, MS, Goethals, S, de Vries, SI, Brette, R & Kole, MHP 2016, 'Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential' Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. 14841-14846. DOI: 10.1073/pnas.1607548113

APA

Hamada, M. S., Goethals, S., de Vries, S. I., Brette, R., & Kole, M. H. P. (2016). Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. Proceedings of the National Academy of Sciences of the United States of America, 113, 14841-14846. DOI: 10.1073/pnas.1607548113

Vancouver

Hamada MS, Goethals S, de Vries SI, Brette R, Kole MHP. Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. Proceedings of the National Academy of Sciences of the United States of America. 2016 Dec 19;113:14841-14846. Available from, DOI: 10.1073/pnas.1607548113

Author

Hamada, Mustafa S ; Goethals, Sarah ; de Vries, Sharon I ; Brette, Romain ; Kole, M.H.P./ Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113. pp. 14841-14846

BibTeX

@article{bc44c809989246e897e7ca0e41c2e470,
title = "Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential",
abstract = "In mammalian neurons, the axon initial segment (AIS) electrically connects the somatodendritic compartment with the axon and converts the incoming synaptic voltage changes into a temporally precise action potential (AP) output code. Although axons often emanate directly from the soma, they may also originate more distally from a dendrite, the implications of which are not well-understood. Here, we show that one-third of the thick-tufted layer 5 pyramidal neurons have an axon originating from a dendrite and are characterized by a reduced dendritic complexity and thinner main apical dendrite. Unexpectedly, the rising phase of somatic APs is electrically indistinguishable between neurons with a somatic or a dendritic axon origin. Cable analysis of the neurons indicated that the axonal axial current is inversely proportional to the AIS distance, denoting the path length between the soma and the start of the AIS, and to produce invariant somatic APs, it must scale with the local somatodendritic capacitance. In agreement, AIS distance inversely correlates with the apical dendrite diameter, and model simulations confirmed that the covariation suffices to normalize the somatic AP waveform. Therefore, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, serving as a homeostatic regulation of the somatic AP in the face of diverse neuronal morphologies.",
author = "Hamada, {Mustafa S} and Sarah Goethals and {de Vries}, {Sharon I} and Romain Brette and M.H.P. Kole",
year = "2016",
month = "12",
day = "19",
doi = "10.1073/pnas.1607548113",
language = "English",
volume = "113",
pages = "14841--14846",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",

}

RIS

TY - JOUR

T1 - Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential

AU - Hamada,Mustafa S

AU - Goethals,Sarah

AU - de Vries,Sharon I

AU - Brette,Romain

AU - Kole,M.H.P.

PY - 2016/12/19

Y1 - 2016/12/19

N2 - In mammalian neurons, the axon initial segment (AIS) electrically connects the somatodendritic compartment with the axon and converts the incoming synaptic voltage changes into a temporally precise action potential (AP) output code. Although axons often emanate directly from the soma, they may also originate more distally from a dendrite, the implications of which are not well-understood. Here, we show that one-third of the thick-tufted layer 5 pyramidal neurons have an axon originating from a dendrite and are characterized by a reduced dendritic complexity and thinner main apical dendrite. Unexpectedly, the rising phase of somatic APs is electrically indistinguishable between neurons with a somatic or a dendritic axon origin. Cable analysis of the neurons indicated that the axonal axial current is inversely proportional to the AIS distance, denoting the path length between the soma and the start of the AIS, and to produce invariant somatic APs, it must scale with the local somatodendritic capacitance. In agreement, AIS distance inversely correlates with the apical dendrite diameter, and model simulations confirmed that the covariation suffices to normalize the somatic AP waveform. Therefore, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, serving as a homeostatic regulation of the somatic AP in the face of diverse neuronal morphologies.

AB - In mammalian neurons, the axon initial segment (AIS) electrically connects the somatodendritic compartment with the axon and converts the incoming synaptic voltage changes into a temporally precise action potential (AP) output code. Although axons often emanate directly from the soma, they may also originate more distally from a dendrite, the implications of which are not well-understood. Here, we show that one-third of the thick-tufted layer 5 pyramidal neurons have an axon originating from a dendrite and are characterized by a reduced dendritic complexity and thinner main apical dendrite. Unexpectedly, the rising phase of somatic APs is electrically indistinguishable between neurons with a somatic or a dendritic axon origin. Cable analysis of the neurons indicated that the axonal axial current is inversely proportional to the AIS distance, denoting the path length between the soma and the start of the AIS, and to produce invariant somatic APs, it must scale with the local somatodendritic capacitance. In agreement, AIS distance inversely correlates with the apical dendrite diameter, and model simulations confirmed that the covariation suffices to normalize the somatic AP waveform. Therefore, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, serving as a homeostatic regulation of the somatic AP in the face of diverse neuronal morphologies.

U2 - 10.1073/pnas.1607548113

DO - 10.1073/pnas.1607548113

M3 - Article

VL - 113

SP - 14841

EP - 14846

JO - Proceedings of the National Academy of Sciences of the United States of America

T2 - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

ER -

ID: 2835064