Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

Geert J P L Kops, Reto Gassmann

Research output: Contribution to journal/periodicalBook/Film/Article reviewScientific

Abstract

The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.

Original languageEnglish
Pages (from-to)653-667
Number of pages15
JournalTrends in Cell Biology
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 2020

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