Decreased body mass index during treatment with sodium oxybate in narcolepsy type 1

TY - JOUR

T1 - Decreased body mass index during treatment with sodium oxybate in narcolepsy type 1

AU - Schinkelshoek, Mink S

AU - Smolders, Isabelle M

AU - Donjacour, Claire E H M

AU - van der Meijden, Wisse P

AU - van Zwet, Erik W

AU - Fronczek, Rolf

AU - Lammers, Gert Jan

N1 - © 2018 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.

PY - 2019

Y1 - 2019

N2 - Narcolepsy type 1 is characterised by an increase in body weight after disease onset, frequently leading to obesity. It was suggested that this weight gain may be counteracted by treatment with sodium oxybate. We here provide longitudinal body mass index data of patients with narcolepsy type 1 after starting treatment with sodium oxybate, compared with patients in whom treatment with modafinil was initiated. Eighty-one individuals with narcolepsy type 1 fulfilled the entry criteria for this retrospective study: 59 had newly started treatment with sodium oxybate and 22 had newly started modafinil. Gender-specific differences between both treatment groups were compared using Student's t tests and mixed effect modeling. Patients using sodium oxybate lost weight, with a mean body mass index decrease of 2.56 kg/m2between the first and last measurement (women; p = .001) and 0.84 kg/m2(men; p = .006). Patients using modafinil, however, gained weight, with a mean body mass index increase of 0.57 kg/m2(women; p = .033) and 0.67 kg/m2(men; p = .122). Medication (p = .006) and baseline body mass index (p = .032) were predictors for body mass index decrease. In conclusion, treatment with sodium oxybate is associated with a body mass index reduction in narcolepsy type 1, whereas modafinil treatment is not. This effect is most pronounced in those who already have a higher baseline body mass index.

AB - Narcolepsy type 1 is characterised by an increase in body weight after disease onset, frequently leading to obesity. It was suggested that this weight gain may be counteracted by treatment with sodium oxybate. We here provide longitudinal body mass index data of patients with narcolepsy type 1 after starting treatment with sodium oxybate, compared with patients in whom treatment with modafinil was initiated. Eighty-one individuals with narcolepsy type 1 fulfilled the entry criteria for this retrospective study: 59 had newly started treatment with sodium oxybate and 22 had newly started modafinil. Gender-specific differences between both treatment groups were compared using Student's t tests and mixed effect modeling. Patients using sodium oxybate lost weight, with a mean body mass index decrease of 2.56 kg/m2between the first and last measurement (women; p = .001) and 0.84 kg/m2(men; p = .006). Patients using modafinil, however, gained weight, with a mean body mass index increase of 0.57 kg/m2(women; p = .033) and 0.67 kg/m2(men; p = .122). Medication (p = .006) and baseline body mass index (p = .032) were predictors for body mass index decrease. In conclusion, treatment with sodium oxybate is associated with a body mass index reduction in narcolepsy type 1, whereas modafinil treatment is not. This effect is most pronounced in those who already have a higher baseline body mass index.

KW - Journal Article

U2 - 10.1111/jsr.12684

DO - 10.1111/jsr.12684

M3 - Article

C2 - 29504180

SN - 0962-1105

VL - 28

JO - Journal of Sleep Research

JF - Journal of Sleep Research

M1 - e12684

ER -