Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

Yorick Post, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.

Original languageEnglish
Pages (from-to)174-183
Number of pages10
JournalCell Stem Cell
Volume25
Issue number2
DOIs
Publication statusPublished - 01 Aug 2019

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