Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis

TY - JOUR

T1 - Defining Adult Stem Cell Function at Its Simplest

T2 - The Ability to Replace Lost Cells through Mitosis

AU - Post, Yorick

AU - Clevers, Hans

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.

AB - Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.

U2 - 10.1016/j.stem.2019.07.002

DO - 10.1016/j.stem.2019.07.002

M3 - Article

C2 - 31374197

SN - 1934-5909

VL - 25

SP - 174

EP - 183

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 2

ER -