Development of microRNA therapeutics is coming of age

Eva van Rooij; Sakari Kauppinen

doi:10.15252/emmm.201100899

Development of microRNA therapeutics is coming of age

Eva van Rooij, Sakari Kauppinen

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

546 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

Original language	English
Pages (from-to)	851-64
Number of pages	14
Journal	EMBO Molecular Medicine
Volume	6
Issue number	7
DOIs	https://doi.org/10.15252/emmm.201100899
Publication status	Published - Jul 2014

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10.15252/emmm.201100899Licence: CC BY

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title = "Development of microRNA therapeutics is coming of age",

abstract = "MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.",

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JO - EMBO Molecular Medicine

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Development of microRNA therapeutics is coming of age

Abstract

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