Development of microRNA therapeutics is coming of age

Eva van Rooij, Sakari Kauppinen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

517 Citations (Scopus)


MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

Original languageEnglish
Pages (from-to)851-64
Number of pages14
JournalEMBO Molecular Medicine
Issue number7
Publication statusPublished - Jul 2014


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