Different flavors of pluripotency, molecular mechanisms, and practical implications

C. Buecker, N. Geijsen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

32 Citations (Scopus)


Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.
Original languageEnglish
Pages (from-to)559-564
JournalCell Stem Cell
Issue number5
Publication statusPublished - 2010


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