Different flavors of pluripotency, molecular mechanisms, and practical implications

TY - JOUR

T1 - Different flavors of pluripotency, molecular mechanisms, and practical implications

AU - Buecker, C.

AU - Geijsen, N.

N1 - Reporting year: 2010

PY - 2010

Y1 - 2010

N2 - Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.

AB - Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.

U2 - 10.1016/j.stem.2010.10.007

DO - 10.1016/j.stem.2010.10.007

M3 - Article

SN - 1934-5909

VL - 7

SP - 559

EP - 564

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -