Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins

TY - JOUR

T1 - Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins

AU - Harterink, M.

AU - Korswagen, H.C.

N1 - Reporting year: 2012

PY - 2012

Y1 - 2012

N2 - The Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the secretion of Wnt proteins requires a specialized trafficking pathway. As this pathway has been discussed in two recent reviews (Lorenowicz & Korswagen 2009, Port & Basler 2010), we will focus our discussion on the key questions that need to be addressed to gain a more complete understanding of the mechanism and regulation of this essential secretion pathway.

AB - The Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the secretion of Wnt proteins requires a specialized trafficking pathway. As this pathway has been discussed in two recent reviews (Lorenowicz & Korswagen 2009, Port & Basler 2010), we will focus our discussion on the key questions that need to be addressed to gain a more complete understanding of the mechanism and regulation of this essential secretion pathway.

U2 - 10.1111/j.1748-1716.2011.02287.x

DO - 10.1111/j.1748-1716.2011.02287.x

M3 - Article

SN - 1748-1708

VL - 204

SP - 8

EP - 16

JO - Acta Physiologica (Oxford, England)

JF - Acta Physiologica (Oxford, England)

IS - 1

ER -