Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Benjamin Egenlauf; Maren Schuhmann; Thomas Giese; Thomas Junghanss; Marija Stojkovic; Kathrin Tintelnot; Sybren de Hoog; Johann Greil; Elvira Richter; Maria Vehresschild; Claus Peter Heussel; Felix J F Herth; Michael Kreuter

doi:10.1159/000493429

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Benjamin Egenlauf, Maren Schuhmann, Thomas Giese, Thomas Junghanss, Marija Stojkovic, Kathrin Tintelnot, Sybren de Hoog, Johann Greil, Elvira Richter, Maria Vehresschild, Claus Peter Heussel, Felix J F Herth, Michael Kreuter

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

Original language	English
Pages (from-to)	472-475
Number of pages	4
Journal	Respiration; international review of thoracic diseases
Volume	97
Issue number	5
DOIs	https://doi.org/10.1159/000493429
Publication status	Published - May 2019

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Egenlauf, B., Schuhmann, M., Giese, T., Junghanss, T., Stojkovic, M., Tintelnot, K., de Hoog, S., Greil, J., Richter, E., Vehresschild, M., Heussel, C. P., Herth, F. J. F., & Kreuter, M. (2019). Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency. Respiration; international review of thoracic diseases, 97(5), 472-475. https://doi.org/10.1159/000493429

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title = "Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency",

abstract = "GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.",

author = "Benjamin Egenlauf and Maren Schuhmann and Thomas Giese and Thomas Junghanss and Marija Stojkovic and Kathrin Tintelnot and {de Hoog}, Sybren and Johann Greil and Elvira Richter and Maria Vehresschild and Heussel, {Claus Peter} and Herth, {Felix J F} and Michael Kreuter",

note = "{\textcopyright} 2019 S. Karger AG, Basel.",

year = "2019",

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doi = "10.1159/000493429",

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Egenlauf, B, Schuhmann, M, Giese, T, Junghanss, T, Stojkovic, M, Tintelnot, K, de Hoog, S, Greil, J, Richter, E, Vehresschild, M, Heussel, CP, Herth, FJF & Kreuter, M 2019, 'Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency', Respiration; international review of thoracic diseases, vol. 97, no. 5, pp. 472-475. https://doi.org/10.1159/000493429

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T1 - Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

AU - Egenlauf, Benjamin

AU - Schuhmann, Maren

AU - Giese, Thomas

AU - Junghanss, Thomas

AU - Stojkovic, Marija

AU - Tintelnot, Kathrin

AU - de Hoog, Sybren

AU - Greil, Johann

AU - Richter, Elvira

AU - Vehresschild, Maria

AU - Heussel, Claus Peter

AU - Herth, Felix J F

AU - Kreuter, Michael

PY - 2019/5

Y1 - 2019/5

N2 - GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

AB - GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

U2 - 10.1159/000493429

DO - 10.1159/000493429

M3 - Article

C2 - 30928982

SN - 0025-7931

VL - 97

SP - 472

EP - 475

JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

IS - 5

ER -

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Abstract

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