Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency

Benjamin Egenlauf, Maren Schuhmann, Thomas Giese, Thomas Junghanss, Marija Stojkovic, Kathrin Tintelnot, Sybren de Hoog, Johann Greil, Elvira Richter, Maria Vehresschild, Claus Peter Heussel, Felix J F Herth, Michael Kreuter

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalRespiration; international review of thoracic diseases
Volume97
Issue number5
DOIs
Publication statusPublished - May 2019

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  • Cite this

    Egenlauf, B., Schuhmann, M., Giese, T., Junghanss, T., Stojkovic, M., Tintelnot, K., de Hoog, S., Greil, J., Richter, E., Vehresschild, M., Heussel, C. P., Herth, F. J. F., & Kreuter, M. (2019). Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency. Respiration; international review of thoracic diseases, 97(5), 472-475. https://doi.org/10.1159/000493429