Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

K.C. da Cunha; D.A. Sutton; A.W. Fothergill; J. Cano; J. Gene; H. Madrid; S. de Hoog; P.W. Crous; J. Guarro

doi:10.1128/JCM.01965-12

Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

K.C. da Cunha, D.A. Sutton, A.W. Fothergill, J. Cano, J. Gene, H. Madrid, S. de Hoog, P.W. Crous, J. Guarro

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Abstract

A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

Original language	English
Pages (from-to)	4061-4066
Journal	Journal of Clinical Microbiology
Volume	50
Issue number	12
DOIs	https://doi.org/10.1128/JCM.01965-12
Publication status	Published - 2012

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title = "Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles",

abstract = "A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.",

author = "{da Cunha}, K.C. and D.A. Sutton and A.W. Fothergill and J. Cano and J. Gene and H. Madrid and {de Hoog}, S. and P.W. Crous and J. Guarro",

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T1 - Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

AU - da Cunha, K.C.

AU - Sutton, D.A.

AU - Fothergill, A.W.

AU - Cano, J.

AU - Gene, J.

AU - Madrid, H.

AU - de Hoog, S.

AU - Crous, P.W.

AU - Guarro, J.

N1 - Reporting year: 2012 Metis note: 3502984

PY - 2012

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N2 - A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

AB - A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

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DO - 10.1128/JCM.01965-12

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EP - 4066

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 12

ER -

Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

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