Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

K.C. da Cunha, D.A. Sutton, A.W. Fothergill, J. Cano, J. Gene, H. Madrid, S. de Hoog, P.W. Crous, J. Guarro

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    58 Citations (Scopus)

    Abstract

    A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.
    Original languageEnglish
    Pages (from-to)4061-4066
    JournalJournal of Clinical Microbiology
    Volume50
    Issue number12
    DOIs
    Publication statusPublished - 2012

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