Ecology and genomics of Actinobacteria: new concepts for natural product discovery

Doris A. van Bergeijk, Barbara R. Terlouw, Marnix H. Medema (Corresponding author), Gilles P. van Wezel (Corresponding author)

Research output: Contribution to journal/periodicalArticleScientificpeer-review

183 Citations (Scopus)
212 Downloads (Pure)


Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic versatility. They produce most of the clinically used antibiotics and a plethora of other natural products with medical or agricultural applications. Modern ‘omics’-based technologies have revealed that the genomic potential of Actinobacteria greatly outmatches the known chemical space. In this Review, we argue that combining insights into actinobacterial ecology with state-of-the-art computational approaches holds great promise to unlock this unexplored reservoir of actinobacterial metabolism. This enables the identification of small molecules and other stimuli that elicit the induction of poorly expressed biosynthetic gene clusters, which should help reinvigorate screening efforts for their precious bioactive natural products.
Original languageEnglish
Pages (from-to)546-558
Number of pages13
JournalNature Reviews Microbiology
Issue number10
Publication statusPublished - 2020


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