Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices

Amer Kamal; Kamiel Spoelstra; Geert Jan Biessels; Ivan J.A. Urban; Willem Hendrik Gispen

doi:10.1016/S0006-8993(99)01215-9

Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices

Amer Kamal, Kamiel Spoelstra, Geert Jan Biessels, Ivan J.A. Urban, Willem Hendrik Gispen^*

^*Corresponding author for this work

NIOO - Animal Ecology (AnE)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

18 Citations (Scopus)

Abstract

The effects of a low or high concentration of glucose in the perfusion medium on synaptic activity and plasticity were studied in hippocampal slices from rats. Low-glucose medium depressed the field excitatory post-synaptic potentials (fEPSP) significantly, whereas high-glucose medium had little effect on the fEPSP. Tetanization of the afferent fibres elicited significant potentiation (LTP) of synaptic activity irrespective of the glucose concentration in the medium. This may indicate that LTP induction does not depend on optimal neural transmission. Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response.

Original language	English
Pages (from-to)	238-242
Number of pages	5
Journal	Brain Research
Volume	824
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01215-9
Publication status	Published - 10 Apr 1999

Keywords

Facilitation
Glucose
Hippocampus
Long-term potentiation
Paired- pulse
Synaptic plasticity

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10.1016/S0006-8993(99)01215-9

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title = "Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices",

abstract = "The effects of a low or high concentration of glucose in the perfusion medium on synaptic activity and plasticity were studied in hippocampal slices from rats. Low-glucose medium depressed the field excitatory post-synaptic potentials (fEPSP) significantly, whereas high-glucose medium had little effect on the fEPSP. Tetanization of the afferent fibres elicited significant potentiation (LTP) of synaptic activity irrespective of the glucose concentration in the medium. This may indicate that LTP induction does not depend on optimal neural transmission. Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response.",

keywords = "Facilitation, Glucose, Hippocampus, Long-term potentiation, Paired- pulse, Synaptic plasticity",

author = "Amer Kamal and Kamiel Spoelstra and Biessels, {Geert Jan} and Urban, {Ivan J.A.} and Gispen, {Willem Hendrik}",

note = "Funding Information: This research is supported by the Dutch Diabetes Foundation, project number: 96125 H.",

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T1 - Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices

AU - Kamal, Amer

AU - Spoelstra, Kamiel

AU - Biessels, Geert Jan

AU - Urban, Ivan J.A.

AU - Gispen, Willem Hendrik

N1 - Funding Information: This research is supported by the Dutch Diabetes Foundation, project number: 96125 H.

PY - 1999/4/10

Y1 - 1999/4/10

N2 - The effects of a low or high concentration of glucose in the perfusion medium on synaptic activity and plasticity were studied in hippocampal slices from rats. Low-glucose medium depressed the field excitatory post-synaptic potentials (fEPSP) significantly, whereas high-glucose medium had little effect on the fEPSP. Tetanization of the afferent fibres elicited significant potentiation (LTP) of synaptic activity irrespective of the glucose concentration in the medium. This may indicate that LTP induction does not depend on optimal neural transmission. Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response.

AB - The effects of a low or high concentration of glucose in the perfusion medium on synaptic activity and plasticity were studied in hippocampal slices from rats. Low-glucose medium depressed the field excitatory post-synaptic potentials (fEPSP) significantly, whereas high-glucose medium had little effect on the fEPSP. Tetanization of the afferent fibres elicited significant potentiation (LTP) of synaptic activity irrespective of the glucose concentration in the medium. This may indicate that LTP induction does not depend on optimal neural transmission. Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response.

KW - Facilitation

KW - Glucose

KW - Hippocampus

KW - Long-term potentiation

KW - Paired- pulse

KW - Synaptic plasticity

U2 - 10.1016/S0006-8993(99)01215-9

DO - 10.1016/S0006-8993(99)01215-9

M3 - Article

C2 - 10196454

AN - SCOPUS:0033541633

SN - 0006-8993

VL - 824

SP - 238

EP - 242

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices

Abstract

Keywords

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