Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

João N de Almeida; Elaine C Francisco; Ferry Hagen; Igor B Brandão; Felicidade M Pereira; Pedro H Presta Dias; Magda M de Miranda Costa; Regiane T de Souza Jordão; Theun de Groot; Arnaldo L Colombo

doi:10.3390/jof7030220

Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

João N de Almeida, Elaine C Francisco, Ferry Hagen, Igor B Brandão, Felicidade M Pereira, Pedro H Presta Dias, Magda M de Miranda Costa, Regiane T de Souza Jordão, Theun de Groot, Arnaldo L Colombo

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Abstract

In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.

Original language	English
Journal	Journal of Fungi
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/jof7030220
Publication status	Published - 17 Mar 2021

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title = "Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit",

abstract = "In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.",

author = "{de Almeida}, {Jo{\~a}o N} and Francisco, {Elaine C} and Ferry Hagen and Brand{\~a}o, {Igor B} and Pereira, {Felicidade M} and {Presta Dias}, {Pedro H} and {de Miranda Costa}, {Magda M} and {de Souza Jord{\~a}o}, {Regiane T} and {de Groot}, Theun and Colombo, {Arnaldo L}",

year = "2021",

month = mar,

day = "17",

doi = "10.3390/jof7030220",

language = "English",

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T1 - Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

AU - de Almeida, João N

AU - Francisco, Elaine C

AU - Hagen, Ferry

AU - Brandão, Igor B

AU - Pereira, Felicidade M

AU - Presta Dias, Pedro H

AU - de Miranda Costa, Magda M

AU - de Souza Jordão, Regiane T

AU - de Groot, Theun

AU - Colombo, Arnaldo L

PY - 2021/3/17

Y1 - 2021/3/17

N2 - In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.

AB - In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.

U2 - 10.3390/jof7030220

DO - 10.3390/jof7030220

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VL - 7

JO - Journal of Fungi

JF - Journal of Fungi

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ER -

Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

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