Emerging pan-resistance in Trichosporon species: a case report

Claudy Oliveira dos Santos, Jan G Zijlstra, Robert J Porte, Greetje A Kampinga, Anne D van Diepeningen, Bhanu Sinha, Erik Bathoorn

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    Abstract

    BACKGROUND: Trichosporon species are ubiquitously spread and known to be part of the normal human flora of the skin and gastrointestinal tract. Trichosporon spp. normally cause superficial infections. However, in the past decade Trichosporon spp. are emerging as opportunistic agents of invasive fungal infections, particularly in severely immunocompromised patients. Clinical isolates are usually sensitive to triazoles, but strains resistant to multiple triazoles have been reported.

    CASE PRESENTATION: We report a high-level pan-azole resistant Trichosporon dermatis isolate causing an invasive cholangitis in a patient after liver re-transplantation. This infection occurred despite of fluconazole and low dose amphotericin B prophylaxis, and treatment with combined liposomal amphotericin B and voriconazole failed.

    CONCLUSION: This case and recent reports in literature show that not only bacteria are evolving towards pan-resistance, but also pathogenic yeasts. Prudent use of antifungals is important to withstand emerging antifungal resistance.

    Original languageEnglish
    Pages (from-to)148
    JournalBMC Infectious Diseases
    Volume16
    DOIs
    Publication statusPublished - 14 Apr 2016

    Keywords

    • Amphotericin B
    • Antifungal Agents
    • Cholangitis
    • Drug Resistance, Fungal
    • Hepatic Encephalopathy
    • Humans
    • Liver Cirrhosis
    • Liver Transplantation
    • Male
    • Microbial Sensitivity Tests
    • Middle Aged
    • Peritonitis
    • Phylogeny
    • Trichosporon
    • Trichosporonosis
    • Voriconazole
    • Case Reports
    • Journal Article

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