Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran

Hamid Badali; Afsane Vaezi; Iman Haghani; Seyed A Yazdanparast; Mohammad T Hedayati; Bita Mousavi; Saham Ansari; Ferry Hagen; Jacques F Meis; Anuradha Chowdhary

doi:10.1111/myc.12089

Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran

Hamid Badali, Afsane Vaezi, Iman Haghani, Seyed A Yazdanparast, Mohammad T Hedayati, Bita Mousavi, Saham Ansari, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary

Westerdijk Fungal Biodiversity Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

96 Citations (Scopus)

Abstract

Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.

Original language	English
Pages (from-to)	659-63
Number of pages	5
Journal	Mycoses
Volume	56
Issue number	6
DOIs	https://doi.org/10.1111/myc.12089
Publication status	Published - Nov 2013

Keywords

Antifungal Agents/pharmacology
Aspergillus fumigatus/drug effects
Azoles/pharmacology
Cytochrome P-450 Enzyme System/genetics
Drug Resistance, Fungal
Environmental Microbiology
Fungal Proteins/genetics
Genotype
Hospitals
Humans
Iran
Mutation, Missense

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10.1111/myc.12089

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@article{06cd4ee38ab44391be6f8cb8a2ec538f,

title = "Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran",

abstract = "Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.",

keywords = "Antifungal Agents/pharmacology, Aspergillus fumigatus/drug effects, Azoles/pharmacology, Cytochrome P-450 Enzyme System/genetics, Drug Resistance, Fungal, Environmental Microbiology, Fungal Proteins/genetics, Genotype, Hospitals, Humans, Iran, Mutation, Missense",

author = "Hamid Badali and Afsane Vaezi and Iman Haghani and Yazdanparast, {Seyed A} and Hedayati, {Mohammad T} and Bita Mousavi and Saham Ansari and Ferry Hagen and Meis, {Jacques F} and Anuradha Chowdhary",

note = "{\textcopyright} 2013 Blackwell Verlag GmbH.",

year = "2013",

month = nov,

doi = "10.1111/myc.12089",

language = "English",

volume = "56",

pages = "659--63",

journal = "Mycoses",

issn = "0933-7407",

publisher = "John Wiley and Sons Ltd",

number = "6",

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TY - JOUR

T1 - Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran

AU - Badali, Hamid

AU - Vaezi, Afsane

AU - Haghani, Iman

AU - Yazdanparast, Seyed A

AU - Hedayati, Mohammad T

AU - Mousavi, Bita

AU - Ansari, Saham

AU - Hagen, Ferry

AU - Meis, Jacques F

AU - Chowdhary, Anuradha

PY - 2013/11

Y1 - 2013/11

N2 - Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.

AB - Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.

KW - Antifungal Agents/pharmacology

KW - Aspergillus fumigatus/drug effects

KW - Azoles/pharmacology

KW - Cytochrome P-450 Enzyme System/genetics

KW - Drug Resistance, Fungal

KW - Environmental Microbiology

KW - Fungal Proteins/genetics

KW - Genotype

KW - Hospitals

KW - Humans

KW - Iran

KW - Mutation, Missense

U2 - 10.1111/myc.12089

DO - 10.1111/myc.12089

M3 - Article

C2 - 23668594

SN - 0933-7407

VL - 56

SP - 659

EP - 663

JO - Mycoses

JF - Mycoses

IS - 6

ER -

Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran

Abstract

Keywords

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