EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

TY - JOUR

T1 - EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

AU - Clevers, J.C.

AU - Batlle, E.

N1 - doi: 10.1158/0008-5472.CAN-05-3849

PY - 2006

Y1 - 2006

N2 - Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.

AB - Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.

M3 - Article

SN - 0008-5472

VL - 66

SP - 2

EP - 5

JO - Cancer Research

JF - Cancer Research

ER -