Epidemiological and mycological characteristics of candidemia in Iran

A. Vaezi; Hamed Fakhim; S. Khodavaisy; A. Alizadeh; M. Nazeri; A. Soleimani; T. Boekhout; H. Badali

doi:10.1016/j.mycmed.2017.02.007

Epidemiological and mycological characteristics of candidemia in Iran

A. Vaezi, Hamed Fakhim, S. Khodavaisy, A. Alizadeh, M. Nazeri, A. Soleimani, T. Boekhout, H. Badali

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

64 Citations (Scopus)

Abstract

To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely a literature search, data extraction and statistical analyses. After a comprehensive literature search, we identified 55 cases. The mean age of patients was 46.80±24.30 years (range 1–81 years). The main risk factors for candidemia were surgery and burns (23.6%), followed by malignancies (20%), use of broad-spectrum antibiotics (18.2%), and diabetes (7.3%). Candida parapsilosis (n=17, 30.8%) was the leading agent, followed by Candida albicans (n=15, 27.3%), Candida glabrata (n=10, 18.2%), and Candida tropicalis (n=8, 14.5%). The frequencies of candidemia cases due to C. glabrata, C. parapsilosis, and C. albicans were significantly higher among patients aged>60, 21–40, and 41–60 years, respectively. Comparison of risk factors for candidemia by multiple logistic regression showed that one of the most important risk factors was surgery (OR: 4.245; 95% CI: 1.141–15.789; P=0.031). The outcome was recorded in only 19 cases and 13 of those patients (68.4%) expired. This study confirms that knowledge of the local epidemiology is important when conducting surveillance studies to prevent and control candidemia and will be of interest for antifungal stewardship.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Journal de Mycologie Médicale
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.mycmed.2017.02.007
Publication status	Published - 2017

Access to Document

10.1016/j.mycmed.2017.02.007

Cite this

@article{2d22c95289a14890b5c16640c0d997be,

title = "Epidemiological and mycological characteristics of candidemia in Iran",

abstract = "To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely a literature search, data extraction and statistical analyses. After a comprehensive literature search, we identified 55 cases. The mean age of patients was 46.80±24.30 years (range 1–81 years). The main risk factors for candidemia were surgery and burns (23.6%), followed by malignancies (20%), use of broad-spectrum antibiotics (18.2%), and diabetes (7.3%). Candida parapsilosis (n=17, 30.8%) was the leading agent, followed by Candida albicans (n=15, 27.3%), Candida glabrata (n=10, 18.2%), and Candida tropicalis (n=8, 14.5%). The frequencies of candidemia cases due to C. glabrata, C. parapsilosis, and C. albicans were significantly higher among patients aged>60, 21–40, and 41–60 years, respectively. Comparison of risk factors for candidemia by multiple logistic regression showed that one of the most important risk factors was surgery (OR: 4.245; 95% CI: 1.141–15.789; P=0.031). The outcome was recorded in only 19 cases and 13 of those patients (68.4%) expired. This study confirms that knowledge of the local epidemiology is important when conducting surveillance studies to prevent and control candidemia and will be of interest for antifungal stewardship.",

author = "A. Vaezi and Hamed Fakhim and S. Khodavaisy and A. Alizadeh and M. Nazeri and A. Soleimani and T. Boekhout and H. Badali",

note = "10.1016/j.mycmed.2017.02.007",

year = "2017",

doi = "10.1016/j.mycmed.2017.02.007",

language = "English",

volume = "27",

pages = "146--152",

journal = "Journal de Mycologie M{\'e}dicale",

issn = "1156-5233",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Epidemiological and mycological characteristics of candidemia in Iran

AU - Vaezi, A.

AU - Fakhim, Hamed

AU - Khodavaisy, S.

AU - Alizadeh, A.

AU - Nazeri, M.

AU - Soleimani, A.

AU - Boekhout, T.

AU - Badali, H.

N1 - 10.1016/j.mycmed.2017.02.007

PY - 2017

Y1 - 2017

N2 - To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely a literature search, data extraction and statistical analyses. After a comprehensive literature search, we identified 55 cases. The mean age of patients was 46.80±24.30 years (range 1–81 years). The main risk factors for candidemia were surgery and burns (23.6%), followed by malignancies (20%), use of broad-spectrum antibiotics (18.2%), and diabetes (7.3%). Candida parapsilosis (n=17, 30.8%) was the leading agent, followed by Candida albicans (n=15, 27.3%), Candida glabrata (n=10, 18.2%), and Candida tropicalis (n=8, 14.5%). The frequencies of candidemia cases due to C. glabrata, C. parapsilosis, and C. albicans were significantly higher among patients aged>60, 21–40, and 41–60 years, respectively. Comparison of risk factors for candidemia by multiple logistic regression showed that one of the most important risk factors was surgery (OR: 4.245; 95% CI: 1.141–15.789; P=0.031). The outcome was recorded in only 19 cases and 13 of those patients (68.4%) expired. This study confirms that knowledge of the local epidemiology is important when conducting surveillance studies to prevent and control candidemia and will be of interest for antifungal stewardship.

AB - To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely a literature search, data extraction and statistical analyses. After a comprehensive literature search, we identified 55 cases. The mean age of patients was 46.80±24.30 years (range 1–81 years). The main risk factors for candidemia were surgery and burns (23.6%), followed by malignancies (20%), use of broad-spectrum antibiotics (18.2%), and diabetes (7.3%). Candida parapsilosis (n=17, 30.8%) was the leading agent, followed by Candida albicans (n=15, 27.3%), Candida glabrata (n=10, 18.2%), and Candida tropicalis (n=8, 14.5%). The frequencies of candidemia cases due to C. glabrata, C. parapsilosis, and C. albicans were significantly higher among patients aged>60, 21–40, and 41–60 years, respectively. Comparison of risk factors for candidemia by multiple logistic regression showed that one of the most important risk factors was surgery (OR: 4.245; 95% CI: 1.141–15.789; P=0.031). The outcome was recorded in only 19 cases and 13 of those patients (68.4%) expired. This study confirms that knowledge of the local epidemiology is important when conducting surveillance studies to prevent and control candidemia and will be of interest for antifungal stewardship.

U2 - 10.1016/j.mycmed.2017.02.007

DO - 10.1016/j.mycmed.2017.02.007

M3 - Article

SN - 1156-5233

VL - 27

SP - 146

EP - 152

JO - Journal de Mycologie Médicale

JF - Journal de Mycologie Médicale

IS - 2

ER -

Epidemiological and mycological characteristics of candidemia in Iran

Abstract

Access to Document

Fingerprint

Cite this