Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

F.H. Brembeck; T. Schwarz-Romond; J. Bakkers; S. Wilhelm; M. Hammerschmidt; W. Birchmeier

doi:10.1101/gad.317604

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

F.H. Brembeck, T. Schwarz-Romond, J. Bakkers, S. Wilhelm, M. Hammerschmidt, W. Birchmeier

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

279 Citations (Scopus)

Abstract

beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

Original language	English
Pages (from-to)	2225-2230
Journal	Genes & Development
Volume	18
Issue number	18
DOIs	https://doi.org/10.1101/gad.317604
Publication status	Published - 2004

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title = "Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.",

abstract = "beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.",

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T1 - Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

AU - Brembeck, F.H.

AU - Schwarz-Romond, T.

AU - Bakkers, J.

AU - Wilhelm, S.

AU - Hammerschmidt, M.

AU - Birchmeier, W.

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N2 - beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

AB - beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

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SP - 2225

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JO - Genes & Development

JF - Genes & Development

IS - 18

ER -

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Abstract

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