Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

A. Bonifaz, G.S. de Hoog, M.R. McGinnis, A. Saul, O. Rodriguez-Cortes, J. Araiza, M.A. Cruz, P. Mercadillo

    Research output: Contribution to journal/periodicalArticleScientificpeer-review


    A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012g/ml.
    Original languageEnglish
    Pages (from-to)111-114
    JournalMedical Mycology
    Issue number1
    Publication statusPublished - 2009


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