Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

TY - JOUR

T1 - Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

AU - Bonifaz, A.

AU - de Hoog, G.S.

AU - McGinnis, M.R.

AU - Saul, A.

AU - Rodriguez-Cortes, O.

AU - Araiza, J.

AU - Cruz, M.A.

AU - Mercadillo, P.

N1 - Reporting year: 2008

PY - 2009

Y1 - 2009

N2 - A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012g/ml.

AB - A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012g/ml.

U2 - 10.1080/13693780802430639

DO - 10.1080/13693780802430639

M3 - Article

SN - 1369-3786

VL - 47

SP - 111

EP - 114

JO - Medical Mycology

JF - Medical Mycology

IS - 1

ER -