Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

Nataliia V. Machushynets; Vladyslav Lysenko; Chao Du; Cornelis J. Slingerland; Somayah S. Elsayed; Mark R. Liles; Nathaniel I. Martin; Gilles P. van Wezel

doi:10.1021/acs.orglett.5c00231

Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

Nataliia V. Machushynets
, Vladyslav Lysenko
, Chao Du
, Cornelis J. Slingerland
, Somayah S. Elsayed
, Mark R. Liles
, Nathaniel I. Martin^*
, Gilles P. van Wezel^* (Corresponding author)

^*Corresponding author for this work

NIOO - Microbial Ecology (ME)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

1 Citation (Scopus)

Abstract

A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.

Original language	English
Pages (from-to)	2821–2825
Journal	Organic Letters
Volume	27
Issue number	12
DOIs	https://doi.org/10.1021/acs.orglett.5c00231
Publication status	Published - Mar 2025

Access to Document

10.1021/acs.orglett.5c00231Licence: CC BY

Cite this

@article{f15738a1bca44639bce699961214d632,

title = "Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B",

abstract = "A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.",

author = "Machushynets, \{Nataliia V.\} and Vladyslav Lysenko and Chao Du and Slingerland, \{Cornelis J.\} and Elsayed, \{Somayah S.\} and Liles, \{Mark R.\} and Martin, \{Nathaniel I.\} and \{van Wezel\}, \{Gilles P.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors. Published by American Chemical Society.",

year = "2025",

month = mar,

doi = "10.1021/acs.orglett.5c00231",

language = "English",

volume = "27",

pages = "2821–2825",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

AU - Machushynets, Nataliia V.

AU - Lysenko, Vladyslav

AU - Du, Chao

AU - Slingerland, Cornelis J.

AU - Elsayed, Somayah S.

AU - Liles, Mark R.

AU - Martin, Nathaniel I.

AU - van Wezel, Gilles P.

PY - 2025/3

Y1 - 2025/3

N2 - A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.

AB - A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.

U2 - 10.1021/acs.orglett.5c00231

DO - 10.1021/acs.orglett.5c00231

M3 - Article

AN - SCOPUS:86000726964

SN - 1523-7060

VL - 27

SP - 2821

EP - 2825

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

Abstract

Access to Document

Fingerprint

Cite this