Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay

Nesrin Kebabcı; Anne D van Diepeningen; Beyza Ener; Tuba Ersal; Martin Meijer; Abdullah M S Al-Hatmi; Vildan Ozkocaman; Ahmet Ursavaş; Ezgi D Cetinoğlu; Halis Akalın

doi:10.1111/myc.12142

Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay

Nesrin Kebabcı, Anne D van Diepeningen, Beyza Ener, Tuba Ersal, Martin Meijer, Abdullah M S Al-Hatmi, Vildan Ozkocaman, Ahmet Ursavaş, Ezgi D Cetinoğlu, Halis Akalın

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

19 Citations (Scopus)

Abstract

Disseminated infections caused by members of the Fusarium fujikuroi species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC-member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65-year-old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission-induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.

Original language	English
Pages (from-to)	249-55
Number of pages	7
Journal	Mycoses
Volume	57
Issue number	4
DOIs	https://doi.org/10.1111/myc.12142
Publication status	Published - Apr 2014

Keywords

Aged
Antigens, Fungal
Aspergillus
Cross Reactions
DNA, Fungal
DNA, Ribosomal Spacer
Diagnosis, Differential
Fusariosis
Fusarium
Humans
Immunoenzyme Techniques
Leukemia, Myeloid, Acute
Male
Mannans
Multilocus Sequence Typing
Tomography, X-Ray Computed

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10.1111/myc.12142

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Kebabcı, N., van Diepeningen, A. D., Ener, B., Ersal, T., Meijer, M., Al-Hatmi, A. M. S., Ozkocaman, V., Ursavaş, A., Cetinoğlu, E. D., & Akalın, H. (2014). Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay. Mycoses, 57(4), 249-55. https://doi.org/10.1111/myc.12142

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title = "Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay",

abstract = "Disseminated infections caused by members of the Fusarium fujikuroi species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC-member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65-year-old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission-induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.",

keywords = "Aged, Antigens, Fungal, Aspergillus, Cross Reactions, DNA, Fungal, DNA, Ribosomal Spacer, Diagnosis, Differential, Fusariosis, Fusarium, Humans, Immunoenzyme Techniques, Leukemia, Myeloid, Acute, Male, Mannans, Multilocus Sequence Typing, Tomography, X-Ray Computed",

author = "Nesrin Kebabcı and {van Diepeningen}, {Anne D} and Beyza Ener and Tuba Ersal and Martin Meijer and Al-Hatmi, {Abdullah M S} and Vildan Ozkocaman and Ahmet Ursava{\c s} and Cetinoğlu, {Ezgi D} and Halis Akalın",

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year = "2014",

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doi = "10.1111/myc.12142",

language = "English",

volume = "57",

pages = "249--55",

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Kebabcı, N, van Diepeningen, AD, Ener, B, Ersal, T, Meijer, M, Al-Hatmi, AMS, Ozkocaman, V, Ursavaş, A, Cetinoğlu, ED & Akalın, H 2014, 'Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay', Mycoses, vol. 57, no. 4, pp. 249-55. https://doi.org/10.1111/myc.12142

TY - JOUR

T1 - Fatal breakthrough infection with Fusarium andiyazi

T2 - new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay

AU - Kebabcı, Nesrin

AU - van Diepeningen, Anne D

AU - Ener, Beyza

AU - Ersal, Tuba

AU - Meijer, Martin

AU - Al-Hatmi, Abdullah M S

AU - Ozkocaman, Vildan

AU - Ursavaş, Ahmet

AU - Cetinoğlu, Ezgi D

AU - Akalın, Halis

PY - 2014/4

Y1 - 2014/4

N2 - Disseminated infections caused by members of the Fusarium fujikuroi species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC-member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65-year-old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission-induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.

AB - Disseminated infections caused by members of the Fusarium fujikuroi species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC-member Fusarium andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65-year-old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission-induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling Fusarium species, according to morphological appearance. The aetiological agent proved to be F. andiyazi based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of F. andiyazi, which had previously only been reported as a plant pathogen affecting various food crops.

KW - Aged

KW - Antigens, Fungal

KW - Aspergillus

KW - Cross Reactions

KW - DNA, Fungal

KW - DNA, Ribosomal Spacer

KW - Diagnosis, Differential

KW - Fusariosis

KW - Fusarium

KW - Humans

KW - Immunoenzyme Techniques

KW - Leukemia, Myeloid, Acute

KW - Male

KW - Mannans

KW - Multilocus Sequence Typing

KW - Tomography, X-Ray Computed

U2 - 10.1111/myc.12142

DO - 10.1111/myc.12142

M3 - Article

C2 - 24612042

SN - 0933-7407

VL - 57

SP - 249

EP - 255

JO - Mycoses

JF - Mycoses

IS - 4

ER -

Fatal breakthrough infection with Fusarium andiyazi: new multi-resistant aetiological agent cross-reacting with Aspergillus galactomannan enzyme immunoassay

Abstract

Keywords

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