Fatal Exophiala infections in China, with a report of seven cases

TY - JOUR

T1 - Fatal Exophiala infections in China, with a report of seven cases

AU - Li, D.M.

AU - Li, R.Y.

AU - de Hoog, G.S.

AU - Sudhadham, M.

AU - Wang, D.L.

N1 - Reporting year: 2010 Metis note: Article first published online: 22 MAR 2010

PY - 2011

Y1 - 2011

N2 - During the past four decades, seven patients were documented in China to have died from Exophiala infections. Causative agents were Exophiala dermatitidis, Exophiala spinifera, Exophiala jeanselmei and a new Exophiala species, Exophiala asiatica. We retrospectively analysed the clinical characteristics of these infections in China and confirmed the identity of aetiological agents of Chinese fatal cases using rDNA ITS sequence analysis. While E. dermatitidis displayed neurotropism, E. spinifera showed osteotropism. The other two species, E. jeanselmei and E. asiatica had caused brain infections in China. Keywords:Black yeast;mycosis;neurotropism;Exophiala;rDNA

AB - During the past four decades, seven patients were documented in China to have died from Exophiala infections. Causative agents were Exophiala dermatitidis, Exophiala spinifera, Exophiala jeanselmei and a new Exophiala species, Exophiala asiatica. We retrospectively analysed the clinical characteristics of these infections in China and confirmed the identity of aetiological agents of Chinese fatal cases using rDNA ITS sequence analysis. While E. dermatitidis displayed neurotropism, E. spinifera showed osteotropism. The other two species, E. jeanselmei and E. asiatica had caused brain infections in China. Keywords:Black yeast;mycosis;neurotropism;Exophiala;rDNA

U2 - 10.1111/j.1439-0507.2010.01859.x

DO - 10.1111/j.1439-0507.2010.01859.x

M3 - Article

SN - 0933-7407

VL - 54

SP - 136

EP - 142

JO - Mycoses

JF - Mycoses

IS - 4

ER -