First Terbinafine-Resistant Trichophyton indotineae Isolates with Phe397Leu and/or Thr414His Mutations in Turkey

TY - JOUR

T1 - First Terbinafine-Resistant Trichophyton indotineae Isolates with Phe397Leu and/or Thr414His Mutations in Turkey

AU - Durdu, Murat

AU - Kandemir, Hazal

AU - Karakoyun, Ayşe Sultan

AU - Ilkit, Macit

AU - Tang, Chao

AU - de Hoog, Sybren

N1 - © 2023. The Author(s), under exclusive licence to Springer Nature B.V.

PY - 2023/1/19

Y1 - 2023/1/19

N2 - Fungal infections of the skin, nails, and hair caused by dermatophyte species continue to be a worldwide concern. The increase in terbinafine-resistant superficial dermatophytosis has become a major concern over the last decade. In this report, we presented two cases of infection with terbinafine-resistant Trichophyton indotineae, the first diagnosis of this species in Turkey. One patient exhibited erythematous pruritic patches and plaques in the inguinal and gluteal regions, while the other patient showed annular erythematous scaly plaques in the bilateral posterior thigh and gluteal regions. One patient harbored a CD36 mutation. Both strains harbored the same amino acid substitution in the squalene epoxidase gene, whereas one isolate had another unknown mutation. Clinical improvement was observed with resveratrol treatment in the patient with the CD36 mutation but not in the other patient.

AB - Fungal infections of the skin, nails, and hair caused by dermatophyte species continue to be a worldwide concern. The increase in terbinafine-resistant superficial dermatophytosis has become a major concern over the last decade. In this report, we presented two cases of infection with terbinafine-resistant Trichophyton indotineae, the first diagnosis of this species in Turkey. One patient exhibited erythematous pruritic patches and plaques in the inguinal and gluteal regions, while the other patient showed annular erythematous scaly plaques in the bilateral posterior thigh and gluteal regions. One patient harbored a CD36 mutation. Both strains harbored the same amino acid substitution in the squalene epoxidase gene, whereas one isolate had another unknown mutation. Clinical improvement was observed with resveratrol treatment in the patient with the CD36 mutation but not in the other patient.

KW - Humans

KW - Antifungal Agents/pharmacology

KW - Drug Resistance, Fungal/genetics

KW - Microbial Sensitivity Tests

KW - Mutation

KW - Terbinafine/pharmacology

KW - Trichophyton/drug effects

KW - Turkey

U2 - 10.1007/s11046-023-00708-2

DO - 10.1007/s11046-023-00708-2

M3 - Article

C2 - 36656402

SN - 0301-486X

VL - 188

SP - 2

JO - Mycopathologia

JF - Mycopathologia

IS - 1

ER -