TY - JOUR
T1 - Five Challenges in the Field of Viral Diversity and Evolution
AU - Sanjuán, Rafael
AU - Illingworth, Christopher J.R.
AU - Geoghegan, Jemma L.
AU - Iranzo, Jaime
AU - Zwart, Mark
AU - Ciota, Alexander T.
AU - Moratorio, Gonzalo
AU - Gago-Zachert, Selma
AU - Duffy, Siobain
AU - Vijaykrishna, Dhanasekaran
N1 - 7352, ME
PY - 2021/4/29
Y1 - 2021/4/29
N2 - Viral diversity and evolution play a central role in processes such as disease emergence, vaccine failure, drug resistance, and virulence. However, significant challenges remain to better understand and manage these processes. Here, we discuss five of these challenges. These include improving our ability to predict viral evolution, developing more relevant experimental evolutionary systems, integrating viral dynamics and evolution at different scales, systematic appraisal of the virosphere, and deepening our understanding of virus-virus interactions. Intensifying future research on these areas should improve our ability to combat viral diseases, as well as to exploit viral diversity and evolution for biotechnological purposes.
AB - Viral diversity and evolution play a central role in processes such as disease emergence, vaccine failure, drug resistance, and virulence. However, significant challenges remain to better understand and manage these processes. Here, we discuss five of these challenges. These include improving our ability to predict viral evolution, developing more relevant experimental evolutionary systems, integrating viral dynamics and evolution at different scales, systematic appraisal of the virosphere, and deepening our understanding of virus-virus interactions. Intensifying future research on these areas should improve our ability to combat viral diseases, as well as to exploit viral diversity and evolution for biotechnological purposes.
KW - international
KW - Plan_S-Compliant_OA
U2 - 10.3389/fviro.2021.684949
DO - 10.3389/fviro.2021.684949
M3 - Article
SN - 2673-818X
VL - 1
SP - 1
EP - 5
JO - Frontiers in Virology
JF - Frontiers in Virology
M1 - 684949
ER -